Rnf145

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August undefined, 2024

WebMar 16, 2024 · Moreover, the tetrapeptide sequence YLYF in the sterol-sensing domain and the Cys-537 residue in the RING finger domain were essential for RNF145 binding to … WebPrEST Antigen RNF145 [Catalog No.: ATL-APrEST80027] Toggle menu. Compare ; Phone: 760-431-4600 / Fax: 760-431-4604; Sign in or Register; Cart 0. Search. CURRENT …

Identification of the ER-resident E3 ubiquitin ligase RNF145 as a …

WebMar 21, 2024 · RNF5 (Ring Finger Protein 5) is a Protein Coding gene. Diseases associated with RNF5 include Inflammatory Bowel Disease 7 and Herpes Simplex Virus … WebJul 10, 2007 · UniProt website fallback message If you are not seeing anything on this page, it might be for multiple reasons: You might have JavaScript disabled: make sure to ... login into xbox live app through website

RNF145 Gene - Somatic Mutations in Cancer - Wellcome Sanger …

WebPrEST Antigen RNF145 [Catalog No.: ATL-APrEST80027] Toggle menu. Compare ; Phone: 760-431-4600 / Fax: 760-431-4604; Sign in or Register; Cart 0. Search. CURRENT PROMOTIONS. WORLDWIDE DISTRIBUTION. CONTACT US. Neurodegeneration Products; CUSABIO dashboard; Fukushima Cancer Gene Overexpressing Cell Lines; WebThe sterol-responsive RNF145 E3 ubiquitin ligase mediates the degradation of HMG-CoA reductase together with gp78 and Hrd1. elife. 2024;7: pubmed publisher . product … WebDec 8, 2024 · Summary. Predicted to enable ubiquitin protein ligase activity. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be … indyne employment

Ubiquitin-mediated regulation of sterol homeostasis - ScienceDirect

Ring finger protein 145 (RNF145) is a ubiquitin ligase for sterol

WebImmunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RNF145 antibody (ab122348) ab122348, at a 1/700 dilution, staining RNF145 in paraffin … WebApr 8, 2024 · Somatic mutations in non-coding regions of the genome and even exonic mutations may have unidentified non-coding consequences which are often overlooked in analysis workflows. Here we present RegTools ([www.regtools.org][1]), a free, open-source software package designed to integrate analysis of somatic variant calls from genomic … login into work microsoft accountWebAug 1, 2024 · Recruitment of RNF145 and gp78 to HMGCR is INSIG-mediated, and we found that RNF145, like HMGCR, binds INSIG1 in a sterol-dependent manner [11∗∗]. Despite near … indy neidell ww2 218

"WebDec 13, 2024 · We find that RNF145 and gp78 independently co-ordinate HMGCR ubiquitination and degradation. RNF145, a sterol-responsive ER-resident E3 ligase, is … " - Rnf145

Rnf145

WebRNF145. ring finger protein 145. UPS Project. GO Process (0) GO Function (0) GO Component (0) CRISPR Database HGNC Alliance of Genome Resources VEGA Entrez … Weblxr还能上调idol和rnf145的表达，前者介导ldlr的降解，后者介导scap的降解。此外，ACAT1和ACAT2可被过量的胆固醇变构激活，再连同LXR介导SREBP1c激活生成的脂肪 …

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WebRNF145 ring finger protein 145 0.905653 LOC145783 uncharacterized LOC145783 0.902879 OR2L13 olfactory receptor, family 2, subfamily L, member 13 0.900854 CREM ... WebJul 30, 2024 · Interleukin-22 (IL-22) plays a role in epithelial barrier function and repair, and may provide benefits in conditions like inflammatory bowel disease. However, limited human data are available to assess the clinical effect of IL-22 administration. This study used a human intestinal cell line to identify an IL-22-dependent gene signature that could serve …

WebHuman pathology. GENERAL INFORMATIONi. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to HGNC. RNF145. WebAug 22, 2024 · RNF145's auto-ubiquitination and degradation are potently inhibited by unsaturated FAs (oleic, arachidonic or eicosapentaenoic acids), allowing RNF145 to …

WebRNF145, a sterol-responsive ER-resident E3 ligase, is unstable but accumulates following sterol depletion. Sterol addition triggers RNF145 recruitment to HMGCR via Insigs, promoting HMGCR ubiquitination and proteasome-mediated degradation. In the absence of both RNF145 and gp78, Hrd1, a third WebRNF145, a sterol-responsive ER-resident E3 ligase, is unstable but accumulates following sterol depletion. Sterol addition triggers RNF145 recruitment to HMGCR via Insigs, …

WebOct 27, 2024 · Transduction of RNF145 into mouse liver inhibits the expression of genes involved in cholesterol biosynthesis and reduces plasma cholesterol levels. Conversely, acute suppression of RNF145 via shRNA-mediated knockdown, or chronic inactivation of RNF145 by genetic deletion, potentiates the expression of cholesterol biosynthetic genes …

WebAug 14, 2024 · We find that RNF145 and gp78, independently co-ordinate HMGCR ubiquitination and degradation. RNF145, a sterol-responsive ER-resident E3 ligase, is … indy neidell ww2 224WebPrimePCR™ Template for SYBR® Green Assay: Rnf145, Rat Reaction: 4 billion copies/200 µl desalted Gene-specific synthetic DNA template designed to give a positive real-time PCR … login in to xfinity emailWebAug 22, 2024 · Here, the E3 ligase RNF145 is found as rheostat to tune levels tuning the levels of the ER-resident lipid hydrolase ADIPOR2 in response to changing fatty acid … indy ncWebApr 1, 2024 · RNF145 expressed at a high level in OSCC cells and circZDBF2 facilitated RNF145 transcription by recruiting the transcription factor CCAAT enhancer binding … login in to xbox on pc groundedWebTogether with the previous findings that Rnf145 is an LXR-regulated gene and that RNF145 inhibits the SREBP pathway through ubiquitinating SCAP, RNF145 serves as an important … indy neidell ww2 190WebBy using this site, you agree to our Terms and Conditions Got it! indy nbcWebRNF145. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project. … indy ncaa football championship