Hplc of atorvastatin
WebI am Ph.D. holder from Vellore Institute of Technology (VIT), Vellore in September 2024. Title of my Ph.D. thesis is “Isolation and characterization of degradation products obtained from forced degradation study of active pharmaceutical ingredient.” I have done MS (Pharm) in pharmaceutical analysis from National Institute of Pharmaceutical Education and … Web4 dec. 2003 · Abstract. A simple high-performance liquid chromatographic (HPLC) method was developed for the analysis of atorvastatin (AT) and its impurities in …
Hplc of atorvastatin
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WebA reverse phase HPLC method was developed for the determination of atorvastatin. The mobile phase involved for the separation was phosphate buffer and acetonitrile with a ratio of 10:1. The HPLC column C 18 ODS hypersil column (250 mm×4.6 mm, 5 μm) was used and detected at 215 nm. The run time of the current method was 5 minutes with excellent … Web1 mei 2015 · Atorvastatin is a synthetic second generation3-hydroxy-3- methylglutaryl-coenzyme (HMG-CoA) reductase inhibitor which lowers plasma cholesterol levels by inhibiting theHMG-CoA reductase that catalyzes the conversion of HMG-CoA to mevalonate, an early and rate-limiting step in cholesterol biosynthesis in the liver [1, 2].
Web12 sep. 2024 · Chemical structure of atorvastatin. The RP-HPLC is a very sensitive analytical technique for estimation of the drug from the formulation as well as a biological sample [ 6 ]. Some HPLC methods for ATS literature have been reported earlier by a researcher, i.e., simultaneous estimation of ATS, amlodipine, and benazepril [ 7, 8 ]. Web1 mei 2024 · An HPLC method was developed and validated to quantify and identify several statins (atorvastatin, fluvastatin, pitavastatin and pravastatin) that were used during …
WebStatins, also known as HMG-CoA reductase inhibitors, are a class of lipid-lowering medications that reduce illness and mortality in those who are at high risk of cardiovascular disease.They are the most common cholesterol-lowering drugs. Low-density lipoprotein (LDL) carriers of cholesterol play a key role in the development of atherosclerosis and … Web1 sep. 2014 · The assay involved an isocratic elution of atorvastatin calcium in a LiChroCART R 250*4 mm HPLC Cartridge LiChrospher R 100 RP-18 (5 µm) column …
Web9 jan. 2011 · A rapid, simple and sensitive high performance liquid chromatography–tandem mass spectrometry (HPLC–MS–MS) method for determination of atorvastatin and amlodipine in plasma of hypertensive patients has been developed and validated to be used for therapeutic drug monitoring. The plasma samples were subjected to methanol protein …
Web2 dagen geleden · The global Atorvastatin Calcium market size was valued at USD 229.94 million in 2024 and is expected to expand at a CAGR of 9.36% during the forecast … buy bust movie analysisWebAtorvastatin is a lipid lowering agent. It is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, the rate-determining enzyme in cholesterol biosynthesis via the mevalonate pathway. Atorvastatin activates autophagy. In vitro. Atorvastatin, one of the statins, inhibits the c-Myc pathway in chronic myeloid leukemia ... celine love doesn\u0027t ask whyWeb29 mei 2013 · Atorvastatin chemically [R- (R*,R*)]-2- (4-Fluorophenyl)- β, δ -dihydroxy-5- (1-methylethyl)-3-phenyl-4- [ (phenylamino)-carboxyl]-1H-pyrrol-1-heptanoic acid calcium salt is a second generation synthetic 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor which decreases de novo cholesterol synthesis (Figure 1 (b) ). buybust movie fullWeb1 nov. 2006 · However, to the best of our knowledge, no HPLC and HPTLC methods have been reported yet for determining the quantity of Atorvastatin and Perindopril … buy bust movie settingWeb7 jan. 2024 · Atorvastatin (AT) (Fig. 1) is one of the oldest and major drug under the class of statins, which is chemically (3R,5R)-7-2- (4-Fluorophenyl)-3-phenyl-4- (phenyl arbamoyl)- 5- propan-2-ylpyrrol-1-yl-3,5-dihydroxyheptanoic acid [ 3] and shows the highest low-density lipoprotein-cholesterol lowering efficacy in human at a maximum daily dose … buy bust operation exampleWeb11 apr. 2024 · The prevalence of type 2 diabetes (T2D) has been growing worldwide; hence, safe and effective antidiabetics are critically warranted. Recently, imeglimin, a novel tetrahydrotriazene compound, has been approved for use in T2D patients in Japan. It has shown promising glucose-lowering properties by improving pancreatic beta-cell function … buybust movie themeWeb2 dagen geleden · Due to the COVID-19 pandemic, the global Atorvastatin Calcium market size is estimated to be worth USD 219 million in 2024 and is forecast to a readjusted size … buy bust movie reaction