Cisplatin hela

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August undefined, 2024

WebMay 26, 2011 · The cisplatin resistant cell line HeLa/CDDP was generated previously under exposure to a clinically relevant concentration of cisplatin (1 µM) and was found to … WebCisplatin is a platinum chemotherapeutic used in a variety of malignancies. The antineoplastic activity occurs from DNA cross-links and adducts, in addition to the generation of superoxide radicals. Nephrotoxicity is the most well-known and potentially most clinically significant toxicity.

Pomiferin targets SERCA, mTOR, and P-gp to induce autophagic …

WebApr 21, 2024 · Cisplatin, as a significant chemotherapeutic drug for the treatment of cancers, was combined with rapamycin (RAPA), an autophagy inducer, or 3 … WebApr 11, 2024 · HIGHLIGHTS who: Umit Aliyaskarova from the Universitu00e9 Nazarbayev University have published the paper: NEIL3-mediated proteasomal degradation facilitates the repair of cisplatin-induced DNA damage in human cells, in the Journal: Scientific … Neil3-mediated proteasomal degradation facilitates the repair of cisplatin-induced dna … software company list in india

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WebMay 15, 2008 · Summary. To study the apoptosis induced by cisplatin in cervical cancer cell line HeLa and its mechanism, cell growth inhibition of cisplatin on HeLa cells … WebAbstract. To study the apoptosis induced by cisplatin in cervical cancer cell line HeLa and its mechanism, cell growth inhibition of cisplatin on HeLa cells was analyzed by … WebThe cis-Diammineplatinum (II) dichloride (cisplatin; P4394), 3- (4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT; M2128), and dimethyl sulfoxide (DMSO; D2650 for cell stock storage and D5979 for drug preparation) were purchased from Sigma (St. Louis, MO, USA). slow descent into alcoholism

Cancers Free Full-Text PARP1-Inhibition Sensitizes Cervical …

Cisplatin-resistant HeLa cells are resistant to apoptosis via …

WebThe chemotherapeutic agent cisplatin, which is a small-molecule platinum compound and was originally found to inhibit bacterial growth and later identified as an anticancer agent, appears to most effectively treat … WebJul 22, 2024 · In contrast, artesunate preferably accumulates in lysosomes, activates lysosome function, and promotes ferritin degradation and free ferrous (Fe 2+) release in HeLa cervical cancer cells . This artesunate-mediated effect on the lysosome and cellular iron accumulation may also occur in HCC cells, and artesunate may further synergize … slow deteriorationWebCisplatin, as a significant chemotherapeutic drug for the treatment of cancers, was combined with rapamycin (RAPA), an autophagy inducer, or 3-methyladenine (3-MA), an autophagy inhibitor, and these cisplatin … slow design examples

"WebWestern Blots showed that cisplatin decreased protein expression of E6 and increased protein expression of P53, p21 and Bax but had no effect on protein expression of … " - Cisplatin hela

Cisplatin hela

MBNL1 regulates resistance of HeLa cells to cisplatin via Nrf2

Web1 day ago · To further confirm the autophagic effect, the expression level of LC3 was detected by immunoblot analysis in HeLa cells, an appropriate tool cells for ... Pomiferin potentiates the tumor suppression effect of cisplatin via attenuating ABCB1 activity and promoting cisplatin accumulation in tumor tissues of RM-1 drug-resistant prostate ... WebIn vitro response to ionizing radiation (IR), cisplatin (cDDP), hyperthermia (HT) and PARP1-inhibition (PARP1- i) as single and combinational treatments in four cervical cancer cell lines (SiHa, HeLa, CaSki and C33A). ( A) Normalized colony formation after IR in combination with cDDP or ( B) with HT.

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WebJan 12, 2024 · Cisplatin-resistant HeLa cells were transfected with NHERF1 and overexpression of NHERF1 protein was confirmed by Western blotting ( Figure 2 A). Effect of NHERF1 on cell growth was examined by CCK8 … WebFeb 1, 2015 · In cell proliferation experiments, HeLa cells were treated with either cisplatin or myricetin and methyl eugenol alone, or vehiclealone for 12, 24 and 48 h. For apoptosis assay, cells weretreated with cisplatin or myricetin and methyl eugenol either alone or combined, or vehicle alone for 48 h.

WebFeb 10, 2024 · Cisplatin is one of the most effective chemotherapy drugs and is widely used in the treatment of cancer, including hepatocellular carcinoma (HCC) and … WebNov 29, 2024 · Cisplatin-resistant A549 non-small cell lung cancer cells can be identified by increased mitochondrial mass and are sensitive to pemetrexed treatment Cisplatin-resistant A549 non-small cell lung cancer cells can be identified by increased mitochondrial mass and are sensitive to pemetrexed treatment

WebAug 21, 2024 · Effect of cisplatin on the proliferative activity and survival of cancer cells. ( A) Viable cell number for HeLa and HeLa-SypHer2 cells. ( B) Percentage of dead (trypan blue positive) cells.... WebSep 18, 2024 · National Center for Biotechnology Information

WebAug 6, 2024 · Cisplatin is a platinum-based chemotherapeutic agent that is widely used for the treatment of malignant tumors, such as cervical cancer, lung cancer, and ovarian cancer [3]. Cisplatin mainly induces cross-linking at the N7-position of guanosine, which modifies DNA to induce apoptosis and kill cancer cells [4].

WebMay 1, 1996 · The intraperitoneal (i.p.) administration of cisplatin (CDDP) is one of the most effective therapies for cancers that are confined to the abdominal cavity. However, the … software company org structureWebNational Center for Biotechnology Information slow design studioWebFeb 12, 2024 · MBNL1 regulates resistance of HeLa cells to cisplatin via Nrf2 Chemotherapy is an important method in the treatment of cervical cancer, but some patients will face drug resistance, which often indicates a poor prognosis. Moreover, there is no complete solution at present. slow design meaningWebFeb 16, 2024 · severe or ongoing nausea and vomiting; vision problems, pain behind your eyes; hearing problems, ringing in your ears; pain, redness, swelling, or skin changes … software company list in davangereWebCisplatin is a chemotherapy drug which is used to treat cancers including: sarcoma, small cell lung cancer, germ cell tumors, lymphoma, and ovarian cancer. While it is often … slow design principlesWebJul 1, 2009 · To test our hypothesis, we employed HeLa Tet (tetracycline)-off cells, which we previously used to overexpress the native plaa gene [21], and determined their apoptotic responses to cisplatin. HeLa cells were chosen because cervical tumor is a cisplatin-responsive tumor, while cervical tissues express the plaa gene [31], and respond to ... software company of indiaWebResults: HeLa and SiHa cells were more sensitive to cisplatin and oxaliplatin treatment than C33A cells. HeLa and SiHa cells had significantly lower NRF2 gene levels, NQO1 … software company ranking wiki